Journal article
Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders
D Eratne, M Kang, C Malpas, S Simpson-Yap, C Lewis, C Dang, J Grewal, A Coe, H Dobson, M Keem, WH Chiu, T Kalincik, S Ooi, D Darby, A Brodtmann, O Hansson, S Janelidze, K Blennow, H Zetterberg, A Walker Show all
Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2024
Abstract
Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show promise to improve diagnosis of neurodegenerative disorders and distinguish neurodegenerative from primary psychiatric disorders (PPD). This study investigated the diagnostic utility of plasma NfL to differentiate behavioural variant frontotemporal dementia (bvFTD, a neurodegenerative disorder commonly misdiagnosed initially as PPD), from PPD, and performance of large normative/reference data sets and models. Methods: Plasma NfL was analysed in major depressive disorder (MDD, n = 42), bipolar affective disorder (BPAD, n = 121), treatment-resistant schizophrenia (TRS, n = 82), bvFTD (n = 22), and compared to..
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Awarded by Alzheimer's Association
Funding Acknowledgements
The authors acknowledge the contribution of the following people: Associate Professor Chad Bousman, Professor Ian Everall, and Associate Professor Mahesh Jayaram. Finally, the authors thank all the participants and their families for their participation.